TUBB3 antibody

Catalog No. ABIN5688672

This Mouse Monoclonal antibody specifically detects TUBB3 in WB and IHC. It exhibits reactivity toward Mammalian.

Quick Overview for TUBB3 antibody (ABIN5688672)

Target: TUBB3 (Tubulin, beta 3 (TUBB3))

Reactivity: Mammalian

Host: Mouse

Clonality: Monoclonal

Conjugate: This TUBB3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: AA10

Product Details anti-TUBB3 Antibody

Specificity: Specific for the ~55  kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1.

Purification: Protein G purified

Immunogen: Synthetic peptide corresponding to beta III tubulin.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Storage: -20 °C

Storage Comment: Beta III Tubulin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Target Details for TUBB3

Target: TUBB3 (Tubulin, beta 3 (TUBB3))

Alternative Name: Beta III Tubulin

Background: Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)

Molecular Weight: 55 kDa

Gene ID: 246118

UniProt: Q4QRB4

Pathways: Microtubule Dynamics, M Phase