TIGIT antibody (Extracellular Domain)

Catalog No. ABIN5688740

This anti-TIGIT antibody is a Mouse Monoclonal antibody detecting TIGIT in ELISA, FACS, ICC, IF and IHC (p). Suitable for Human.

Quick Overview for TIGIT antibody (Extracellular Domain) (ABIN5688740)

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIGIT antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7A5

Product Details anti-TIGIT Antibody

Binding Specificity: Extracellular Domain

Purification: TIGIT Antibody is supplied as protein A purified IgG2b.

Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT.

Isotype: IgG2b

Application Details

Application Notes: TIGIT antibody can be used for immunohistochemistry starting at 2 - 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TIGIT Antibody is supplied in PBS containing 0.02% sodium azide and 50 % glycerol rather

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: TIGIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TIGIT

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Alternative Name: TIGIT

Background: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity, this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

Molecular Weight: Predicted: 26 kDa

Gene ID: 201633

NCBI Accession: NP_776160

UniProt: Q495A1

Pathways: Cancer Immune Checkpoints