GRIN1/NMDAR1 antibody

Catalog No. ABIN5688952

The Rabbit Polyclonal anti-GRIN1/NMDAR1 antibody has been validated for WB and IHC. It is suitable to detect GRIN1/NMDAR1 in samples from Rat.

Quick Overview for GRIN1/NMDAR1 antibody (ABIN5688952)

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN1/NMDAR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GRIN1/NMDAR1 Antibody

Purification: Affinity Purified

Immunogen: NMDA NR1, Splice Variant N1 polyclonal antibody was raised against a peptide containing the N1 insert.

Application Details

Application Notes: NMDA NR1, Splice Variant N1 antibody allows for strong and specific immunolabeling of the NR1 subunit containing the N1 splice variant insert. This product does not recognize NR1 subunits that do not contain the N1 insert. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB). Rabbit anti-NMDA NR1, Splice Variant N1 recognizes NR1 in rat and mouse brain. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Storage: -20 °C

Storage Comment: NMDA NR1, Splice Variant N1 antibody can be stored at -20°C. After reconstitution in 50 μ,l PBS, the antibody should be aliquot and stored at -20°C and is stable at -20°C for at least 1 year. Ambient shipment is suitable for both international and domestic.

Target Details for GRIN1/NMDAR1

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Alternative Name: NMDA NR1

Background: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity. There are a number of different splice variants of the NR1. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.

Molecular Weight: 120 kDa

Gene ID: 24408

UniProt: P35439

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity