Cortactin antibody (AA 464-468)

Catalog No. ABIN5689261

The Rabbit Polyclonal anti-Cortactin antibody has been validated for WB and IHC. It is suitable to detect Cortactin in samples from Human, Mouse and Rat.

Quick Overview for Cortactin antibody (AA 464-468) (ABIN5689261)

Target: Cortactin (CTTN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cortactin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Cortactin Antibody

Binding Specificity: AA 464-468

Specificity: This antibody detects endogenous level of total Cortactin protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Cortactin (Ab-466) antibody was raised against a peptide sequence around aa.464~468 (P-V-Y-E-T) derived from Human CORTACTIN.

Application Details

Application Notes: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for Cortactin

Target: Cortactin (CTTN)

Alternative Name: Cortactin

Background: Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Molecular Weight: 85 kDa

Gene ID: 2017

NCBI Accession: NP_005222

UniProt: Q14247

Pathways: MAPK Signaling