BIM antibody (AA 67-71)

Catalog No. ABIN5689506

This Rabbit Polyclonal antibody specifically detects BIM in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for BIM antibody (AA 67-71) (ABIN5689506)

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-BIM Antibody

Binding Specificity: AA 67-71

Specificity: This antibody detects endogenous level of total BIM protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: BIM (Ab-69) antibody was raised against a peptide sequence around aa.67~71 (P-A-S-P-G) derived from Human BIM.

Application Details

Application Notes: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for BIM

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Alternative Name: BIM

Background: Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.

Molecular Weight: 23 kDa

Gene ID: 10018

NCBI Accession: NP_006529

UniProt: O43521

Pathways: PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity