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CHEK2 antibody (AA 514-518)

This Rabbit Polyclonal antibody specifically detects CHEK2 in WB. It exhibits reactivity toward Human.

Catalog No. ABIN5689596

Datasheet as PDF

Quick Overview for CHEK2 antibody (AA 514-518) (ABIN5689596)

Target

See all CHEK2 Antibodies

CHEK2 (Checkpoint Kinase 2 (CHEK2))

Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Conjugate

This CHEK2 antibody is un-conjugated

Application

Western Blotting (WB)

Discover our top product CHEK2 Primary Antibody

Binding Specificity
26

25

19

17

16

16

15

15

9

8

8

8

6

5

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 514-518

Specificity

This antibody detects endogenous levels of total Chk2 protein.

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen

Chk2 (Ab-516) antibody was raised against a peptide sequence around aa. 514~518 (Q-P-S-T-S) derived from Chk2.
anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibody
CHEK2 Reactivity: Human WB, IF, IHC (p), FACS Host: Rabbit Polyclonal RB19067 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 4B7 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 Reactivity: Human, Dog WB, IHC, IP, IHC (p), FACS Host: Mouse Monoclonal 2H5 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 Reactivity: Human, Dog WB, IHC, IF, IP, IHC (p), FACS Host: Mouse Monoclonal 5C4 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 Reactivity: Human, Monkey, Dog WB, IHC, IF, IHC (p), FACS Host: Mouse Monoclonal 10G7 unconjugated

Application Notes

Western Blot: 1:500~1:1000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store antibody at -20°C for up to one year.
Target

CHEK2 (Checkpoint Kinase 2 (CHEK2))

Alternative Name

Chk2

Background

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Molecular Weight

62 kDa

Gene ID

11200

NCBI Accession

NP_001005735

UniProt

O96017

Pathways

p53 Signaling, Apoptosis, Cell Division Cycle