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KAP1 antibody (AA 827-831)

This anti-KAP1 antibody is a Rabbit Polyclonal antibody detecting KAP1 in WB. Suitable for Human, Mouse and Rat.
Catalog No. ABIN5689604

Quick Overview for KAP1 antibody (AA 827-831) (ABIN5689604)

Target

See all KAP1 (TRIM28) Antibodies
KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Reactivity

  • 114
  • 54
  • 52
  • 10
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  • 9
  • 7
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
Human, Mouse, Rat

Host

  • 117
  • 17
  • 4
Rabbit

Clonality

  • 108
  • 30
Polyclonal

Conjugate

  • 72
  • 8
  • 8
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This KAP1 antibody is un-conjugated

Application

  • 91
  • 48
  • 42
  • 28
  • 27
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  • 20
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  • 8
  • 4
  • 4
  • 3
  • 2
  • 2
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  • 1
  • 1
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 23
    • 15
    • 10
    • 8
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 827-831

    Specificity

    This antibody detects endogenous level of total TIF1β, protein.

    Purification

    Antibodies were purified by affinity-chromatography using epitope-specific peptide.

    Immunogen

    TIF1beta antibody was raised against a peptide sequence around aa.827~831 (L-S-G-G-P) derived from Human TIF1β,.
  • Application Notes

    Western Blot: 1:500~1:1000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store antibody at -20°C for up to one year.
  • Target

    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

    Alternative Name

    TIF1beta

    Background

    Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.

    Molecular Weight

    110 kDa

    Gene ID

    10155

    NCBI Accession

    NP_005753

    UniProt

    Q13263

    Pathways

    Hedgehog Signaling, Positive Regulation of Response to DNA Damage Stimulus
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