MAP2K5 antibody (pSer311, pThr315)

Catalog No. ABIN5689662

This Rabbit Polyclonal antibody specifically detects MAP2K5 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MAP2K5 antibody (pSer311, pThr315) (ABIN5689662)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP2K5 Antibody

Binding Specificity: pSer311, pThr315

Specificity: This antibody detects endogenous level of MEK5 only when phosphorylated at serine 311 or threonine 315.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Immunogen: MEK5 (phospho-Ser311/ Thr315) antibody was raised against a peptide sequence around phosphorylation site of Serine 311 and threonine 315 (V-N-S (p) I-A-K-T (p) -Y-V) derived from Rat MEK5.

Application Details

Application Notes: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Alternative Name: MEK5

Background: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.

Molecular Weight: 46 kDa

Gene ID: 29568

NCBI Accession: NP_001029159

UniProt: Q62862

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway