BimEL antibody (AA 20-70)

Catalog No. ABIN5689905

This Rabbit Polyclonal antibody specifically detects BimEL in WB, ELISA, ICC and IF. It exhibits reactivity toward Rat, Human and Mouse.

Quick Overview for BimEL antibody (AA 20-70) (ABIN5689905)

Target: BimEL

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BimEL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-BimEL Antibody

Binding Specificity: AA 20-70

Specificity: Bim EL antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist, this antibody only detects the Bim EL isoform.

Purification: Bim EL Antibody is affinity chromatography purified via peptide column.

Immunogen: Bim EL antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bim.

The immunogen is located within amino acids 20 - 70 of Bim EL.

Isotype: IgG

Application Details

Application Notes: Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bim EL Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Bim EL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for BimEL

Target: BimEL

Alternative Name: Bim EL

Background: Bim EL Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).

Molecular Weight: Predicted: 22 kDa

Observed: 24 kDa

Gene ID: 10018

NCBI Accession: NP_619527

UniProt: O43521