BTLA antibody

Catalog No. ABIN5690631

This Rat Monoclonal antibody specifically detects BTLA in FACS, ELISA and Func. It exhibits reactivity toward Human.

Quick Overview for BTLA antibody (ABIN5690631)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This BTLA antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Clone: 6F4

Product Details anti-BTLA Antibody

Specificity: Recognizes human BTLA.

Purity: > 95% (SDS-PAGE)

Immunogen: Ectodomain of human BTLA fused to human IgG Fc.

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry: (frozen sections).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol.

Storage: -20 °C

Storage Comment: Stable for at least 1 year after receipt when stored at -20°C.

Target Details for BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Alternative Name: BTLA

Background: B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

Gene ID: 151888

NCBI Accession: NP_861445

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints