HMBS antibody (AA 6-361)

Catalog No. ABIN5692868

Product Details anti-HMBS Antibody

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Binding Specificity: AA 6-361

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMBS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Brand: Picoband™

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for HMBS detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.

Immunogen: E. coli-derived human HMBS recombinant protein (Position: N6-H361).

Application Details

Application Notes:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot,0.1-0.5 μg/mL
Direct ELISA,0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Target Details for HMBS

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Alternative Name: HMBS (HMBS Products)

Synonyms: PBG-D antibody, PBGD antibody, PORC antibody, UPS antibody, URO-S antibody, hemC antibody, pbg-d antibody, pbgd antibody, ups antibody, SPAC806.01 antibody, DDBDRAFT_0186148 antibody, DDBDRAFT_0231417 antibody, DDB_0186148 antibody, DDB_0231417 antibody, Hmbs antibody, NV50236 antibody, T25658 antibody, Ups antibody, Uros1 antibody, hmbs antibody, zgc:64128 antibody, hmbsl antibody, id:ibd5004 antibody, im:7140060 antibody, zgc:110690 antibody, hydroxymethylbilane synthase antibody, hydroxymethylbilane synthase S homeolog antibody, hydroxymethylbilane synthase L homeolog antibody, hydroxymethylbilane synthase (predicted) antibody, Hydroxymethylbilane synthase antibody, hydroxymethylbilane synthase a antibody, hydroxymethylbilane synthase, b antibody, HMBS antibody, Hmbs antibody, hmbs antibody, hmbs.2.S antibody, hmbs.L antibody, CNC02250 antibody, hem3 antibody, hemC antibody, Trad_0335 antibody, Plabr_2100 antibody, Sgly_3113 antibody, SMLT_RS19660 antibody, PMI_RS16580 antibody, hmbsa antibody, hmbsb antibody

Background:

Synonyms: Porphobilinogen deaminase, PBG-D, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase, HMBS, PBGD, UPS

Tissue Specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is found only in erythroid cells.

Background: Porphobilinogen deaminase (hydroxymethylbilane synthase, or uroporphyrinogen I synthase) is an enzyme that in humans is encoded by the HMBS gene. This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

UniProt: P08397