CASR antibody (AA 926-1078)

Catalog No. ABIN5693096

This anti-CASR antibody is a Mouse Monoclonal antibody detecting CASR in WB. Suitable for Human.

Quick Overview for CASR antibody (AA 926-1078) (ABIN5693096)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CASR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 11E9

Product Details anti-CASR Antibody

Binding Specificity: AA 926-1078

Purpose: Anti-CASR Antibody (monoclonal, 11E9)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-CASR Antibody (monoclonal, 11E9) (ABIN5693096). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

Isotype: IgG2b

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Alternative Name: CASR

Background:

Synonyms: Extracellular calcium-sensing receptor, CaR

Tissue Specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.

Background: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Molecular Weight: 130 kDa

Gene ID: 846

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis