MUC2 antibody

Catalog No. ABIN5693242

The Rabbit Polyclonal anti-MUC2 antibody has been validated for IHC and IF. It is suitable to detect MUC2 in samples from Human, Mouse and Rat.

Quick Overview for MUC2 antibody (ABIN5693242)

Target: MUC2 (Mucin 2, Oligomeric Mucus/gel-Forming (MUC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUC2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MUC2 Antibody

Purpose: Anti-MUC2 Antibody

Sequence: DDFKTASGLV EATGAGFANT WKAQSTCHDK LDWLDD

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-MUC2 Antibody Picoband® (ABIN5693242). Tested in IF, IHC applications. This antibody reacts with Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human MUC2, which shares 86.1% amino acid (aa) sequence identity with both mouse and rat MUC2.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunofluorescence, 5 μg/mL, Human, Mouse
1. Allen, A., Hutton, D. A., Pearson, J. P. The MUC2 gene product: a human intestinal mucin. Int. J. Biochem. Cell Biol. 30: 797-801, 1998. 2. Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004). "The complete genomic organization of the human MUC6 and MUC2 mucin genes". Genomics 83 (5): 936-9.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for MUC2

Target: MUC2 (Mucin 2, Oligomeric Mucus/gel-Forming (MUC2))

Alternative Name: MUC2

Background:

Synonyms: Mucin-2, MUC-2, Intestinal mucin-2, MUC2, SMUC

Tissue Specificity: Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

Background: Mucin 2, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. This gene encodes a member of the mucin protein family. It is mapped to 11p15.5. Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80 % by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium. The primary function of the MUC2 gene product is to provide a protective barrier between the epithelial surfaces and the gut lumen. There is decreased expression of MUC2 in colonic cancer and defective polymerization of secreted mucin in ulcerative colitis.

Molecular Weight: 38 kDa

Gene ID: 4583

UniProt: Q02817