GRM2 antibody (Internal Region)

Catalog No. ABIN569585

The Goat Polyclonal anti-GRM2 antibody is suitable to detect GRM2 in samples from Human, Rat, Mouse, Cow, Dog and Rabbit. It has been validated for WB, IHC (p) and EIA.

Quick Overview for GRM2 antibody (Internal Region) (ABIN569585)

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reactivity: Human, Rat, Mouse, Cow, Dog, Rabbit

Host: Goat

Clonality: Polyclonal

Conjugate: This GRM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-GRM2 Antibody

Binding Specificity: Internal Region

Sequence: C-KETAPERREV

Specificity: This antibody is expected to recognize both isoforms of GRM2 (NP_000830.2 and NP_001123535.1).

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog), Bovine, Rabbit.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of Human GRM2 (NP_000830.2, NP_001123535.1). Genename: GRM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GRM2

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Alternative Name: mGluR2 / GRM2

Background: The Metabotropic Glutamate Receptor GRM2 binds L-glutamate and has been linked to the inhibition of the cyclic AMP signaling cascade. GRM2 is involved in mediating the suppression of neurotransmission and in synaptogenesis and synaptic stabilization. Glutamatergic neurotransmission plays a role in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.Synonyms: GPRC1B, Metabotropic glutamate receptor 2

Gene ID: 2912

NCBI Accession: NP_000830

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport