PROX1 antibody (C-Term)

Catalog No. ABIN569679

The Rabbit Polyclonal anti-PROX1 antibody (ABIN569679) specifically detects PROX1 in WB, IHC (p) and IHC (fro). The antibody is reactive with Human, Mouse, Rat and Fish samples.

Quick Overview for PROX1 antibody (C-Term) (ABIN569679)

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Reactivity: Human, Mouse, Rat, Fish

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PROX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PROX1 Antibody

Binding Specificity: C-Term

Specificity: This antibody is reactive with Prox-1. It will be a useful tool to study lymphatic vessel density in and around human tumors. It will detect Prox-1 in the nucleus of lymphatic endothelial cells.

Purification: Purified

Immunogen: Peptide corresponding to the Homeobox domain of Prox1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store lyophilized (preferably in a desiccator) at -20 °C and in aliquots at -80 °C. Reconstituted antibody can be stored at 4 °C for a limited period of time, it does not show decline in activity after two weeks at 4 °C.

Target Details for PROX1

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Alternative Name: PROX-1

Background: The homeobox gene Prox-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. Prox-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. Prox-1-deficient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. Human Prox-1 gene has been mapped to chromosome 1q32.2-q32.3, and its product shows 94 % similarity to the chicken protein. The conserved structure and expression pattern of the Prox-1 gene imply that it may play the same roles in humans as in other vertebrates. The human Prox-1 gene is most actively expressed in the developing lens. Anti-Prox-1 antibodies provide a highly specific marker of lymphatic endothelial cells.Synonyms: Homeobox prospero-like protein PROX1, PROX1, Prospero homeobox protein 1

Gene ID: 5629

NCBI Accession: NP_002754

UniProt: Q92786

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation