RAB7B antibody

Catalog No. ABIN5698229

The Rabbit Polyclonal anti-RAB7B antibody is suitable to detect RAB7B in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for RAB7B antibody (ABIN5698229)

Target: RAB7B (RAB7B, Member RAS Oncogene Family (RAB7B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB7B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RAB7B Antibody

Purpose: RAB7B antibody

Immunogen: RAB7B, member RAS oncogene family

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

human heart tissue were subjected to SDS PAGE followed by western blot with FNab07044(RAB7B antibody) at dilution of 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RAB7B

Target: RAB7B (RAB7B, Member RAS Oncogene Family (RAB7B))

Alternative Name: RAB7B

Background:

Synonyms: Ras-related protein Rab-7b|RAB7B

Background: Controls vesicular trafficking from endosomes to the trans-Golgi network(TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF-and EGFR degradation pathway.

Gene ID: 338382

UniProt: Q96AH8