MYLK antibody

Catalog No. ABIN5699678

The Rabbit Polyclonal anti-MYLK antibody has been validated for WB, ELISA and IF. It is suitable to detect MYLK in samples from Human, Mouse and Rat.

Quick Overview for MYLK antibody (ABIN5699678)

Target: MYLK (Myosin Light Chain Kinase (MYLK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYLK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-MYLK Antibody

Purpose: MYLK antibody

Immunogen: myosin light chain kinase

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MYLK

Target: MYLK (Myosin Light Chain Kinase (MYLK))

Alternative Name: MYLK

Background:

Synonyms: Myosin light chain kinase, smooth muscle (MLCK, smMLCK)|Kinase-related protein (KRP)|Telokin|Myosin light chain kinase, smooth muscle, deglutamylated form|MYLK|MLCK|MLCK1|MYLK1

Background: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

Molecular Weight: 135 kDa

Gene ID: 4638

UniProt: Q15746