MMP14 antibody (AA 100-200)

Catalog No. ABIN5703940

This Rabbit Polyclonal antibody specifically detects MMP14 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse, Rat and Zebrafish (Danio rerio).

Quick Overview for MMP14 antibody (AA 100-200) (ABIN5703940)

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-MMP14 Antibody

Binding Specificity: AA 100-200

Purpose: MMP14 antibody

Immunogen:

Immunogen sequence: 100-200aa,Extracellular domain

Immunogen: matrix metallopeptidase 14 (membrane-inserted)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MMP14

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Alternative Name: MMP14

Background:

Synonyms: Matrix metalloproteinase-14 (MMP-14)|MMP-X1|Membrane-type matrix metalloproteinase 1 (MT-MMP 1, MTMMP1)|Membrane-type-1 matrix metalloproteinase (MT1-MMP, MT1MMP)|MMP14

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Gene ID: 4323

UniProt: P50281

Pathways: Autophagy