Recombinant MUC6 antibody

Catalog No. ABIN5707610

This Rabbit Monoclonal antibody specifically detects MUC6 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant MUC6 antibody (ABIN5707610)

Target: MUC6 (Mucin 6, Oligomeric Mucus/gel-Forming (MUC6))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MUC6 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MUCN6-2R

Product Details anti-MUC6 Antibody

Purpose: Recombinant MUC6 Antibody / Gastric Mucin / Rabbit Monoclonal

Purification: Protein A affinity chromatography

Immunogen: A peptide from the Mucin-6 tandem repeat sequence was used as the immunogen for the recombinant MUC6 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the recombinant MUC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant MUC6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MUC6

Target: MUC6 (Mucin 6, Oligomeric Mucus/gel-Forming (MUC6))

Alternative Name: MUC6

Background: MUC6 or gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2, Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.

UniProt: Q6W4X9