ABCC1
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
1G8
unconjugated
Application Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MRP1 antibody to be titered up or down for optimal performance.\. Western blot: 0.5-1 μg/mL,FACS: 0.5-1 μg/10^6 cells,Immunofluorescence: 1-2 μg/mL
Restrictions
For Research Use only
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Preservative
Azide free
Storage
4 °C,-20 °C
Storage Comment
Store the MRP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Target
ABCC1
(ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1))
Alternative Name
MRP1 / ABCC1
Background
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood.