PRKDC antibody

Catalog No. ABIN576237

This anti-PRKDC antibody is a Rabbit Polyclonal antibody detecting PRKDC in WB, IHC, IP, IHC (p) and GS. Suitable for Human, Mouse, Rat and Hamster.

Quick Overview for PRKDC antibody (ABIN576237)

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Reactivity: Human, Mouse, Rat, Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKDC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Gel Shift (GS)

Product Details anti-PRKDC Antibody

Specificity: Recognizes the human DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, DNPK1 or p460. DNA PKcs is a 4128 amino acid ~460 kD nuclear protein encoded by the PRKDC gene, acting as a molecular sensor for DNA damage. Mutation of the PRKDC gene can result in Immunodeficiency 26 with or without neurologic abnormalities.

Immunogen: Human DNA-PKcs fragment.

Isotype: IgG

Application Details

Application Notes: Approved: GS, IHC, IHC-P (1:100), IP, WB (1:2000)

Usage: Immunohistology: This product requires heat mediated treatment of paraffin sections. We recommend the use of antigen unmasking fluid for this purpose. A two hour incubation with LS-C42724 is recommended.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Serum, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for PRKDC

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Alternative Name: PRKDC / DNA-PKcs

Background: Name/Gene ID: PRKDC
Subfamily: PI3/PI4
Family: Protein Kinase

Synonyms: PRKDC, DNA-PK, DNAPK, DNPK1, HYRC, HYRC1, p350, Scid, XRCC7, DNA-PK catalytic subunit, DNA-PKcs, p460, DNA-dependent protein kinase catalytic subunit

Gene ID: 5591

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response