Tyrosine Hydroxylase antibody
Quick Overview for Tyrosine Hydroxylase antibody (ABIN576288)
Target
See all Tyrosine Hydroxylase (TH) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Specificity
- Recognizes tyrosine hydroxylase (TH). Tyrosine hydroxylase catalyses the rate-limiting step in the biosynthetic pathway of the catecholamines dopamine (DA), norepinephrine, and epinephrine. The enzyme exists as a tetramer, with each subunit composed of an N-terminal regulatory domain and a C-terminal catalytic domain. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.
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Purification
- Purified
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Immunogen
- Tyrosine hydroxylase purified from pheochromocytoma.
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Isotype
- IgG
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Application Notes
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Approved: IF (1:1000), IHC, IHC-Fr (1:1000), WB (1:1000)
Usage: Western Blot: LS-C43105 detects a band of approximately 60kD in rat caudate cell lysates. -
Comment
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Target Species of Antibody: Rat
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- 10 mM HEPES, pH 7.5, 0.09 % sodium azide, 0.01 % BSA, 50 % glycerol.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Tyrosine Hydroxylase (TH)
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Alternative Name
- TH / Tyrosine Hydroxylase
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Background
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Name/Gene ID: TH
Family: Monooxygenase
Synonyms: TH, DYT14, Dystonia 14, TYH, Tyrosine 3-hydroxylase, Tyrosine hydroxylase, DYT5b, Tyrosine 3-monooxygenase -
Gene ID
- 7054
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Pathways
- Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
Target
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