Connexin 31 antibody (pSer368)

Catalog No. ABIN576289

This Rabbit Monoclonal antibody specifically detects Connexin 31 in WB. It exhibits reactivity toward Rat.

Quick Overview for Connexin 31 antibody (pSer368) (ABIN576289)

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Reactivity: Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Connexin 31 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Connexin 31 Antibody

Binding Specificity: pSer368

Specificity: Recognizes the ~43 kD Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C. A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes.

Purification: Purified

Immunogen: Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 ( pSer368 ).

Type of Immunogen: Synthetic phospho-peptide

Isotype: IgG

Application Details

Application Notes: Approved: WB (1:1000)

Usage: Western Blot: LS-C43142 detects a band of approximately 43kD in rat hippocampus cell lysates.

Comment:

Target Species of Antibody: Rat

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 10 mM HEPES,  pH 7.5, 0.09 % sodium azide, 0.01 % BSA, 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Connexin 31

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Alternative Name: GJB3 / CX31 / Connexin 31

Background: Name/Gene ID: GJB3
Subfamily: Connexin
Family: Ion Channel

Synonyms: GJB3, Connexin 31, Connexin-31, CX31, DFNA2, Erythrokeratodermia variabilis, Gap junction beta-3 protein, DFNA2B, EKV, Gap junction protein beta 3

Gene ID: 2707

Pathways: Sensory Perception of Sound