ICT1 antibody (AA 30-206)

Catalog No. ABIN5775998

The Mouse Monoclonal anti-ICT1 antibody (Clone AT1E9) (ABIN5775998) specifically detects ICT1 in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for ICT1 antibody (AA 30-206) (ABIN5775998)

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: AT1E9

Product Details anti-ICT1 Antibody

Binding Specificity: AA 30-206

Purpose: Human ICT1 antibody

Purification: Purified

Immunogen: Recombinant human ICT1 (30-206aa) purified from E. coli

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for ICT1

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Alternative Name: ICT1

Background: Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas.

NCBI Accession: NP_001536