PKM antibody (AA 1-531)

Catalog No. ABIN5776015

The Mouse Monoclonal anti-PKM antibody has been validated for ELISA, WB, IF and ICC. It is suitable to detect PKM in samples from Human.

Quick Overview for PKM antibody (AA 1-531) (ABIN5776015)

Target: PKM (Pyruvate Kinase M1/2 (PKM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PKM antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AT1B10

Product Details anti-PKM Antibody

Binding Specificity: AA 1-531

Immunogen: Recombinant human PKM2 (1-531aa) purified from E.coli

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details for PKM

Target: PKM (Pyruvate Kinase M1/2 (PKM))

Alternative Name: PKM

Background: PKM2 (pyruvate kinase M2), its association with phospho-tyrosine (pTyr) motifs, enables cells to use predominantly aerobic glycolysis instead of oxidative phosphorylation. Also PKM2 suggest that this change benefits cancer cells by enabling them to redirect glycolytic metabolites away from oxidation and energy production and, instead, toward anabolic processes and biosynthesis. PKM2-mediated generation of the aerobic glycolytic phenotype, although wasteful in terms of glucose consumption and waste generation, could provide a variety of advantages for cancerous cells. In addition nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.

NCBI Accession: NP_002645

Pathways: Warburg Effect