AKR1C1 antibody (AA 1-323)

Catalog No. ABIN5776092

This Mouse Monoclonal antibody specifically detects AKR1C1 in WB, ELISA, IF, ICC and FACS. It exhibits reactivity toward Human.

Quick Overview for AKR1C1 antibody (AA 1-323) (ABIN5776092)

Target: AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AKR1C1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: AT6D10

Product Details anti-AKR1C1 Antibody

Binding Specificity: AA 1-323

Purpose: Human Aldo-keto Reductase 1C1/AKR1C1 antibody

Purification: Purified

Immunogen: Recombinant human AKR1C1 (1-323aa) purified from E. coli

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for AKR1C1

Target: AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

Alternative Name: Aldo-keto Reductase 1C1/AKR1C1

Background: The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) have major roles in pre receptor regulation of progesterone action. They can both convert progesterone to the less potent efficiencies. AKR1C1 and AKR1C3 also act as 3-ketosteroid reductase, and as such they can convert the most potent androgen 5alpha-DHT into 3beta-andorstandiol, which is an estrogen receptor beta ligand, and into the inactive androgen 3alpha-androstnionl, respectively.

NCBI Accession: NP_001344

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process