TBC1D4 antibody (pThr642)

Catalog No. ABIN5955761

Product Details anti-TBC1D4 Antibody

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Binding Specificity: pThr642

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Acrg embryonic lethality (mouse) minimal region ortholog,Acrg embryonic lethality minimal region ortholog,Acrg embryonic lethality mouse minimal region ortholog,Akt substrate of 160 kDa,AS 160,AS160,BUB2,CDC16,KIAA0603,NIDDM5,TBC (Tre 2 BUB2 CDC16) domain containing protein,TBC Tre 2 BUB2 CDC16 domain containing protein,TBC1 D4,TBC1 domain family member 4,Tbc1d4,TBCD4,Tre-2

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human TBC1D4 around the phosphorylation site of Thr642

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TBC1D4

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Alternative Name: TBC1D4 (TBC1D4 Products)

Background: TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.

Molecular Weight: 147kDa

Gene ID: 9882

UniProt: O60343