RAD51 antibody (Tyr315)

Catalog No. ABIN5958191

This Rabbit Polyclonal antibody specifically detects RAD51 in WB, ELISA and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for RAD51 antibody (Tyr315) (ABIN5958191)

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RAD51 Antibody

Binding Specificity: Tyr315

Specificity: BRCA1/BRCA2 containing complex,subunit 5,BRCC 5,BRCC5,DNA repair protein RAD51 homolog 1,DNA repair protein rhp51,FANCR,hRAD51,HsRAD51,HsT16930,MRMV2,Rad 51,RAD51,RAD51 homolog (RecA homolog,E. coli) (S. cerevisiae),RAD51 homolog A,RAD51 homolog,RAD51 recombinase,RAD51,S. cerevisiae,homolog of,RAD51,RAD51A,RECA,RecA like protein,RecA,E. coli,homolog of,Recombination protein A

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human Rad51 around the non-phosphorylation site of Tyr315.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RAD51

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Alternative Name: Rad51

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, whicHuman, Mouseay be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 37kDa

Gene ID: 5888

UniProt: Q06609

Pathways: DNA Damage Repair