TERT antibody (Ser824)

Catalog No. ABIN5958627

The Rabbit Polyclonal anti-TERT antibody has been validated for WB and ELISA. It is suitable to detect TERT in samples from Human.

Quick Overview for TERT antibody (Ser824) (ABIN5958627)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TERT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TERT Antibody

Binding Specificity: Ser824

Specificity: CMM9,DKCA2,DKCB4,EST2,HEST2,htert,hTRT,PFBMFT1,TCS1,Telomerase associated protein 2,Telomerase catalytic subunit,Telomerase reverse transcriptase,Telomerase-associated protein 2,Telomere Reverse Transcriptase,TERT,TERT,TP2,TRT

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human TERT around the non-phosphorylation site of Ser824.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Alternative Name: TERT

Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Molecular Weight: 127kDa

Gene ID: 7015

UniProt: O14746

Pathways: Telomere Maintenance