Myosin VI antibody

Catalog No. ABIN5958676

The Rabbit Polyclonal anti-Myosin VI antibody (ABIN5958676) specifically detects Myosin VI in WB, ELISA and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Myosin VI antibody (ABIN5958676)

Target: Myosin VI (MYO6)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Myosin VI antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Myosin VI Antibody

Specificity: Deafness autosomal recessive 37,DFNA 22,DFNA22,DFNB 37,DFNB37,KIAA0389,MYO 6,Myo6,MYO6,Myosin VI,Myosin-VI,Myosin6,Unconventional myosin-6,Unconventional myosin-VI

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the N-terminal region of human Myosin VI

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:5000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Myosin VI

Target: Myosin VI (MYO6)

Alternative Name: Myosin VI

Background: This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. MYO6 (Myosin VI) is a Protein Coding gene. Diseases associated with MYO6 include Deafness, Autosomal Dominant 22 and Deafness, Autosomal Recessive 37. Among its related pathways are PAK Pathway and Vesicle-mediated transport. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYO7A.

Molecular Weight: 150kDa

Gene ID: 4646

UniProt: Q9UM54

Pathways: Sensory Perception of Sound, Dicarboxylic Acid Transport, Asymmetric Protein Localization