Caspase 3 antibody

Catalog No. ABIN5960895

The Rabbit Polyclonal anti-Caspase 3 antibody has been validated for WB and ELISA. It is suitable to detect Caspase 3 in samples from Human and Monkey.

Quick Overview for Caspase 3 antibody (ABIN5960895)

Target: Caspase 3 (CASP3)

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Caspase 3 Antibody

Specificity: A830040C14Rik,Apopain,CASP-3,CASP3,CASP3,Casp3a,Caspase 3,Caspase 3,apoptosis-related cysteine peptidase,Caspase 3,apoptosis-related cysteine protease,Caspase 3,apoptosis-related cysteine protease a,Caspase-3 subunit p12,CC3,CPP-32,CPP32,CPP32B,Cysteine protease CPP32,EC 3.4.22.56,LICE,mldy,OTTHUMP00000165052,OTTHUMP00000165053,OTTHUMP00000165054,PARP cleavage protease,Procaspase3,Protein Yama,SCA 1,SCA-1,SREBP cleavage activity 1,Yama

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the N-terminal region of human Caspase-3

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:40000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Caspase 3

Target: Caspase 3 (CASP3)

Alternative Name: Caspase-3

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Molecular Weight: 32kDa

Gene ID: 836

UniProt: P42574

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation