DCC antibody

Catalog No. ABIN6133664

Product Details anti-DCC Antibody

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCC antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide of human DCC

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DCC

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Alternative Name: DCC (DCC Products)

Background: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.,DCC,CRC18,CRCR1,IGDCC1,MRMV1,NTN1R1,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Apoptosis,Neuroscience,DCC

Molecular Weight: 158 kDa

Gene ID: 1630

UniProt: P43146

Pathways: Regulation of Cell Size