ABCB1 antibody (AA 600-700)

Catalog No. ABIN6136339

The Rabbit Polyclonal anti-ABCB1 antibody has been validated for WB and IF. It is suitable to detect ABCB1 in samples from Human.

Quick Overview for ABCB1 antibody (AA 600-700) (ABIN6136339)

Target: ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ABCB1 Antibody

Binding Specificity: AA 600-700

Sequence: GFDDGVIVEK GNHDELMKEK GIYFKLVTMQ TAGNEVELEN AADESKSEID ALEMSSNDSR SSLIRKRSTR RSVRGSQAQD RKLSTKEALD ESIPPVSFWR I

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 600-700 of human P Glycoprotein (NP_000918.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ABCB1

Target: ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))

Alternative Name: ABCB1

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.,ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,P Glycoprotein,ABCB1,Cancer,Drug resistance,P glycoproteins,Signal Transduction,Endocrine & Metabolism,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,ABCB1

Molecular Weight: 134 kDa/141 kDa

Gene ID: 5243

UniProt: P08183