Angiopoietin 1 antibody (AA 260-400)

Catalog No. ABIN6136873

The Rabbit Polyclonal anti-Angiopoietin 1 antibody has been validated for WB and IHC. It is suitable to detect Angiopoietin 1 in samples from Human. There is 1 publication available.

Quick Overview for Angiopoietin 1 antibody (AA 260-400) (ABIN6136873)

Target: Angiopoietin 1 (ANGPT1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiopoietin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Angiopoietin 1 Antibody

Binding Specificity: AA 260-400

Sequence: NLVNLCTKEV LLKGGKREEE KPFRDCADVY QAGFNKSGIY TIYINNMPEP KKVFCNMDVN GGGWTVIQHR EDGSLDFQRG WKEYKMGFGN PSGEYWLGNE FIFAITSQRQ YMLRIELMDW EGNRAYSQYD RFHIGNEKQN Y

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 260-400 of human ANGPT1 (NP_001186788.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Angiopoietin 1 antibody (ABIN6136873)

Huang, Han, Sun, Zhao, Liu, Yuan, Mao, Peng, Liu, Yin, He: "Kv1.3 channel blocker (ImKTx88) maintains blood-brain barrier in experimental autoimmune encephalomyelitis." in: Cell & bioscience, Vol. 7, pp. 31, (2017) (PubMed).

Target Details for Angiopoietin 1

Target: Angiopoietin 1 (ANGPT1)

Alternative Name: ANGPT1

Background: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,ANGPT1,AGP1,AGPT,ANG1,Cancer,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Cardiovascular,Angiogenesis,Hypoxia,ANGPT1

Molecular Weight: 57 kDa

Gene ID: 284

UniProt: Q15389

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process