APOE antibody (AA 200-300)

Catalog No. ABIN6137017

This Rabbit Polyclonal antibody specifically detects APOE in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for APOE antibody (AA 200-300) (ABIN6137017)

Target: APOE (Apolipoprotein E (APOE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APOE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-APOE Antibody

Binding Specificity: AA 200-300

Sequence: GPLVEQGRVR AATVGSLAGQ PLQERAQAWG ERLRARMEEM GSRTRDRLDE VKEQVAEVRA KLEEQAQQIR LQAEAFQARL KSWFEPLVED MQRQWAGLVE K

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human APOE (NP_000032.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for APOE

Target: APOE (Apolipoprotein E (APOE))

Alternative Name: ApoE

Background: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.,APOE,AD2,APO-E,ApoE4,LDLCQ5,LPG,ApoE,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Stem Cells,Cardiovascular,Lipids,Lipoproteins/Apolipoproteins,ApoE

Molecular Weight: 36 kDa

Gene ID: 348

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism