Amphiregulin antibody (AA 20-252)

Catalog No. ABIN6137065

This Rabbit Polyclonal antibody specifically detects Amphiregulin in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for Amphiregulin antibody (AA 20-252) (ABIN6137065)

Target: Amphiregulin (AREG)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiregulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Amphiregulin Antibody

Binding Specificity: AA 20-252

Sequence: SGHYAAGLDL NDTYSGKREP FSGDHSADGF EVTSRSEMSS GSEISPVSEM PSSSEPSSGA DYDYSEEYDN EPQIPGYIVD DSVRVEQVVK PPQNKTESEN TSDKPKRKKK GGKNGKNRRN RKKKNPCNAE FQNFCIHGEC KYIEHLEAVT CKCQQEYFGE RCGEKSMKTH SMIDSSLSKI ALAAIAAFMS AVILTAVAVI TVQLRRQYVR KYEGEAEERK KLRQENGNVH AIA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-252 of human AREG (NP_001648.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: AREG

Background: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.,AREG,AR,AREGB,CRDGF,SDGF,amphiregulin,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,Immunology & Inflammation,Cytokines,AREG

Molecular Weight: 27 kDa

Gene ID: 374

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway