Asialoglycoprotein Receptor 2 antibody (AA 131-287)

Catalog No. ABIN6137182

This Rabbit Polyclonal antibody specifically detects Asialoglycoprotein Receptor 2 in WB. It exhibits reactivity toward Human.

Quick Overview for Asialoglycoprotein Receptor 2 antibody (AA 131-287) (ABIN6137182)

Target: Asialoglycoprotein Receptor 2 (ASGR2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Asialoglycoprotein Receptor 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Asialoglycoprotein Receptor 2 Antibody

Binding Specificity: AA 131-287

Sequence: VDLRFVACQM ELLHSNGSQR TCCPVNWVEH QGSCYWFSHS GKAWAEAEKY CQLENAHLVV INSWEEQKFI VQHTNPFNTW IGLTDSDGSW KWVDGTDYRH NYKNWAVTQP DNWHGHELGG SEDCVEVQPD GRWNDDFCLQ VYRWVCEKRR NATGEVA

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 131-287 of human ASGR2 (NP_550435.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Asialoglycoprotein Receptor 2

Target: Asialoglycoprotein Receptor 2 (ASGR2)

Alternative Name: ASGR2

Background: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,ASGR2,ASGP-R2,ASGPR2,CLEC4H2,HBXBP,HL-2,Signal Transduction,ASGR2

Molecular Weight: 32 kDa/35 kDa

Gene ID: 433

UniProt: P07307

Pathways: Thyroid Hormone Synthesis