AVPR2 antibody (AA 232-371)

Catalog No. ABIN6137379

This Rabbit Polyclonal antibody specifically detects AVPR2 in WB. It exhibits reactivity toward Human.

Quick Overview for AVPR2 antibody (AA 232-371) (ABIN6137379)

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVPR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AVPR2 Antibody

Binding Specificity: AA 232-371

Sequence: IHASLVPGPS ERPGGRRRGR RTGSPGEGAH VSAAVAKTVR MTLVIVVVYV LCWAPFFLVQ LWAAWDPEAP LEGAPFVLLM LLASLNSCTN PWIYASFSSS VSSELRSLLC CARGRTPPSL GPQDESCTTA SSSLAKDTSS

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 232-371 of human AVPR2 (NP_000045.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for AVPR2

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Alternative Name: AVPR2

Background: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.,AVPR2,ADHR,DI1,DIR,DIR3,NDI,V2R,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,AVPR2

Molecular Weight: 33 kDa/40 kDa

Gene ID: 554

UniProt: P30518

Pathways: cAMP Metabolic Process