CISH antibody (AA 1-257)

Catalog No. ABIN6138639

This Rabbit Polyclonal antibody specifically detects CISH in WB. It exhibits reactivity toward Human.

Quick Overview for CISH antibody (AA 1-257) (ABIN6138639)

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CISH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CISH Antibody

Binding Specificity: AA 1-257

Sequence: MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC LPLPRRMADY LRQYPFQ

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human CISH (NP_659508.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Alternative Name: CISH

Background: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.,CISH,BACTS2,CIS,CIS-1,G18,SOCS,Epigenetics & Nuclear Signaling,Signal Transduction,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,CISH

Molecular Weight: 28 kDa/29 kDa/30 kDa

Gene ID: 1154

UniProt: Q9NSE2

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus