DDR2 antibody (AA 290-400)

Catalog No. ABIN6139473

This anti-DDR2 antibody is a Rabbit Polyclonal antibody detecting DDR2 in WB. Suitable for Human.

Quick Overview for DDR2 antibody (AA 290-400) (ABIN6139473)

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DDR2 Antibody

Binding Specificity: AA 290-400

Sequence: NMFAKGVKIF KEVQCYFRSE ASEWEPNAIS FPLVLDDVNP SARFVTVPLH HRMASAIKCQ YHFADTWMMF SEITFQSDAA MYNNSEALPT SPMAPTTYDP MLKVDDSNTR I

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_001014796.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DDR2

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Alternative Name: DDR2

Background: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.,DDR2,MIG20a,NTRKR3,TKT,TYRO10,Signal Transduction,Kinase,Tyrosine kinases,Immunology & Inflammation,CD markers,Neuroscience,Cardiovascular,Heart,Cardiogenesis,DDR2

Molecular Weight: 96 kDa

Gene ID: 4921

UniProt: Q16832

Pathways: RTK Signaling