DERL1 antibody (AA 182-251)

Catalog No. ABIN6139538

This Rabbit Polyclonal antibody specifically detects DERL1 in WB. It exhibits reactivity toward Human.

Quick Overview for DERL1 antibody (AA 182-251) (ABIN6139538)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DERL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DERL1 Antibody

Binding Specificity: AA 182-251

Sequence: LYFFLMFRYP MDLGGRNFLS TPQFLYRWLP SRRGGVSGFG VPPASMRRAA DQNGGGGRHN WGQGFRLGDQ

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 182-251 of human DERL1 (NP_077271.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Alternative Name: DERL1

Background: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.,DERL1,DER-1,DER1,derlin-1,Signal Transduction,Neuroscience,Neurodegenerative Diseases,DERL1

Molecular Weight: 26 kDa/28 kDa

Gene ID: 79139

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling