Desmoglein 1 antibody (AA 800-1049)

Catalog No. ABIN6139829

This anti-Desmoglein 1 antibody is a Rabbit Polyclonal antibody detecting Desmoglein 1 in WB and IF. Suitable for Human.

Quick Overview for Desmoglein 1 antibody (AA 800-1049) (ABIN6139829)

Target: Desmoglein 1 (DSG1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Desmoglein 1 Antibody

Binding Specificity: AA 800-1049

Sequence: SPHFGTTTVI SESTYPSGPG VLHPKPILDP LGYGNVTVTE SYTTSDTLKP SVHVHDNRPA SNVVVTERVV GPISGADLHG MLEMPDLRDG SNVIVTERVI APSSSLPTSL TIHHPRESSN VVVTERVIQP TSGMIGSLSM HPELANAHNV IVTERVVSGA GVTGISGTTG ISGGIGSSGL VGTSMGAGSG ALSGAGISGG GIGLSSLGGT ASIGHMRSSS DHHFNQTIGS ASPSTARSRI TKYSTVQYSK

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 800-1049 of human DSG1 (NP_001933.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: DSG1

Background: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.,DSG1,CDHF4,DG1,DSG,EPKHE,EPKHIA,PPKS1,SPPK1,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cadherins,Cytoskeleton,Neuroscience,Calcium Signaling,DSG1

Molecular Weight: 42 kDa/113 kDa

Gene ID: 1828

UniProt: Q02413

Pathways: Cell-Cell Junction Organization