DUSP12 antibody (AA 130-270)

Catalog No. ABIN6139861

This anti-DUSP12 antibody is a Rabbit Polyclonal antibody detecting DUSP12 in WB. Suitable for Human.

Quick Overview for DUSP12 antibody (AA 130-270) (ABIN6139861)

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DUSP12 Antibody

Binding Specificity: AA 130-270

Sequence: LMKTDQLPFE KAYEKLQILK PEAKMNEGFE WQLKLYQAMG YEVDTSSAIY KQYRLQKVTE KYPELQNLPQ ELFAVDPTTV SQGLKDEVLY KCRKCRRSLF RSSSILDHRE GSGPIAFAHK RMTPSSMLTT GRQAQCTSYF I

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-270 of human DUSP12 (NP_009171.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DUSP12

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Alternative Name: DUSP12

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.,DUSP12,DUSP1,YVH1,Signal Transduction,DUSP12

Molecular Weight: 37 kDa

Gene ID: 11266

UniProt: Q9UNI6

Pathways: Regulation of Carbohydrate Metabolic Process