FGFR1 antibody (AA 300-400)

Catalog No. ABIN6140610

The Rabbit Polyclonal anti-FGFR1 antibody has been validated for WB. It is suitable to detect FGFR1 in samples from Human.

Quick Overview for FGFR1 antibody (AA 300-400) (ABIN6140610)

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGFR1 Antibody

Binding Specificity: AA 300-400

Sequence: IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR NVSFEDAGEY TCLAGNSIGL SHHSAWLTVL EALEERPAVM TSPLYLEIII YCTGAFLISC MVGSVIVYKM K

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human FGFR1 (NP_075598.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Alternative Name: FGFR1

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.,FGFR1,BFGFR,CD331,CEK,ECCL,FGFBR,FGFR-1,FLG,FLT-2,FLT2,HBGFR,HH2,HRTFDS,KAL2,N-SAM,OGD,bFGF-R-1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,ESC Pluripotency and Differentiation,Immunology & Inflammation,CD markers,Neuroscience,Cardiovascular,Angiogenesis,FGFR1

Molecular Weight: 6 kDa/16 kDa/33 kDa/55-95 kDa

Gene ID: 2260

UniProt: P11362

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins