FMR1 antibody (AA 500-600)

Catalog No. ABIN6140719

The Rabbit Polyclonal anti-FMR1 antibody has been validated for WB, IHC and IF. It is suitable to detect FMR1 in samples from Human.

Quick Overview for FMR1 antibody (AA 500-600) (ABIN6140719)

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FMR1 Antibody

Binding Specificity: AA 500-600

Sequence: SETESDHRDE LSDWSLAPTE EERESFLRRG DGRRRGGGGR GQGGRGRGGG FKGNDDHSRT DNRPRNPREA KGRTTDGSLQ IRVDCNNERS VHTKTLQNTS S

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500-600 of human FMRP (NP_002015.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IHC,1:50 - 1:200,IF,1:100 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FMR1

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Alternative Name: FMR1

Background: The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.,FMRP,FRAXA,POF,POF1,FMR1,POFX,Epigenetics & Nuclear Signaling,RNA Binding,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Neuron marker,Dendrite marker,Synapse marker,FMR1

Molecular Weight: 58 kDa/61 kDa/66 kDa/68 kDa/69 kDa/70 kDa/71 kDa

Gene ID: 2332

UniProt: Q06787

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development