GALE antibody (AA 129-348)

Catalog No. ABIN6140933

This anti-GALE antibody is a Rabbit Polyclonal antibody detecting GALE in WB and IHC. Suitable for Human.

Quick Overview for GALE antibody (AA 129-348) (ABIN6140933)

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GALE Antibody

Binding Specificity: AA 129-348

Sequence: FSSSATVYGN PQYLPLDEAH PTGGCTNPYG KSKFFIEEMI RDLCQADKTW NAVLLRYFNP TGAHASGCIG EDPQGIPNNL MPYVSQVAIG RREALNVFGN DYDTEDGTGV RDYIHVVDLA KGHIAALRKL KEQCGCRIYN LGTGTGYSVL QMVQAMEKAS GKKIPYKVVA RREGDVAACY ANPSLAQEEL GWTAALGLDR MCEDLWRWQK QNPSGFGTQA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE (NP_001121093.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GALE

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Alternative Name: GALE

Background: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.,GALE,SDR1E1,Cancer,Signal Transduction,Endocrine & Metabolism,Carbohydrate metabolism,GALE

Molecular Weight: 30 kDa/38 kDa

Gene ID: 2582

UniProt: Q14376

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process