GEN1 antibody (AA 669-908)

Catalog No. ABIN6141058

The Rabbit Polyclonal anti-GEN1 antibody has been validated for WB. It is suitable to detect GEN1 in samples from Human.

Quick Overview for GEN1 antibody (AA 669-908) (ABIN6141058)

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GEN1 Antibody

Binding Specificity: AA 669-908

Sequence: LQDLPLKERI FTKLSYPQDN LQPDVNLKTL SILSVKESCI ANSGSDCTSH LSKDLPGIPL QNESRDSKIL KGDQLLQEDY KVNTSVPYSV SNTVVKTCNV RPPNTALDHS RKVDMQTTRK ILMKKSVCLD RHSSDEQSAP VFGKAKYTTQ RMKHSSQKHN SSHFKESGHN KLSSPKIHIK ETEQCVRSYE TAENEESCFP DSTKSSLSSL QCHKKENNSG TCLDSPLPLR QRLKLRFQST

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 669-908 of human GEN1 (NP_872431.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GEN1

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Alternative Name: GEN1

Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.,GEN1,Gen,Epigenetics & Nuclear Signaling,DNA Damage & Repair,GEN1

Molecular Weight: 102 kDa

Gene ID: 348654

UniProt: Q17RS7

Pathways: DNA Damage Repair