GNE antibody (AA 1-150)

Catalog No. ABIN6141232

This anti-GNE antibody is a Rabbit Polyclonal antibody detecting GNE in WB and IHC. Suitable for Human.

Quick Overview for GNE antibody (AA 1-150) (ABIN6141232)

Target: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GNE Antibody

Binding Specificity: AA 1-150

Sequence: METYGYLQRE SCFQGPHELY FKNLSKRNKQ IMEKNGNNRK LRVCVATCNR ADYSKLAPIM FGIKTEPEFF ELDVVVLGSH LIDDYGNTYR MIEQDDFDIN TRLHTIVRGE DEAAMVESVG LALVKLPDVL NRLKPDIMIV HGDRFDALAL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GNE (NP_001121699.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GNE

Target: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Alternative Name: GNE

Background: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.,GNE,DMRV,GLCNE,IBM2,NM,Uae1,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cardiovascular,Blood,GNE

Molecular Weight: 66 kDa/71 kDa/78 kDa/79 kDa/83 kDa

Gene ID: 10020

UniProt: Q9Y223