Metabotropic Glutamate Receptor 1 antibody (AA 920-1140)

Catalog No. ABIN6141420

The Rabbit Polyclonal anti-Metabotropic Glutamate Receptor 1 antibody has been validated for WB. It is suitable to detect Metabotropic Glutamate Receptor 1 in samples from Human.

Quick Overview for Metabotropic Glutamate Receptor 1 antibody (AA 920-1140) (ABIN6141420)

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Metabotropic Glutamate Receptor 1 Antibody

Binding Specificity: AA 920-1140

Sequence: NETACNQTAV IKPLTKSYQG SGKSLTFSDT STKTLYNVEE EEDAQPIRFS PPGSPSMVVH RRVPSAATTP PLPSHLTAEE TPLFLAEPAL PKGLPPPLQQ QQQPPPQQKS LMDQLQGVVS NFSTAIPDFH AVLAGPGGPG NGLRSLYPPP PPPQHLQMLP LQLSTFGEEL VSPPADDDDD SERFKLLQEY VYEHEREGNT EEDELEEEEE DLQAASKLTP D

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 920-1140 of human GRM1 (NP_000829.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Alternative Name: GRM1

Background: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.,GRM1,GPRC1A,MGLU1,MGLUR1,PPP1R85,SCAR13,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,Neurodegenerative Diseases,GRM1

Molecular Weight: 101 kDa/132 kDa

Gene ID: 2911

UniProt: Q13255