HECTD1 antibody (AA 2518-2610)

Catalog No. ABIN6141706

This anti-HECTD1 antibody is a Rabbit Polyclonal antibody detecting HECTD1 in WB. Suitable for Human.

Quick Overview for HECTD1 antibody (AA 2518-2610) (ABIN6141706)

Target: HECTD1 (HECT Domain Containing 1 (HECTD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HECTD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HECTD1 Antibody

Binding Specificity: AA 2518-2610

Sequence: PGFLRFVRVL CGMSSDERKA FLQFTTGCST LPPGGLANLH PRLTVVRKVD ATDASYPSVN TCVHYLKLPE YSSEEIMRER LLAATMEKGF HLN

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2518-2610 of human HECTD1 (NP_056197.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HECTD1

Target: HECTD1 (HECT Domain Containing 1 (HECTD1))

Alternative Name: HECTD1

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.,HECTD1,EULIR,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Ubiquitin,HECTD1

Molecular Weight: 289 kDa

Gene ID: 25831

UniProt: Q9ULT8

Pathways: Tube Formation, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection